Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL73100 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL1303277 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL276988 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL5471628 | 0.97 | CA4 (0.89) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL2235356 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL445486 | 0.97 | CA4 (0.89) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL3657 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL715802 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL11060179 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL9780898 | 0.95 | CA4 (0.85) | CA4CASP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1348 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121805475-B | Detection method of bromarol diamide in ginger | Shandong maker detection Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122017257-A | Detection method and detection kit for oxidized low-density lipoprotein | 济南玖方生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260060973-A1 | Ophthalmic Composition for Treating Non-Infectious Inflammatory Diseases | VIVAVISION BIOTECH LTD (CN) | 2026-03-05 | — | — | US | claimed |
| EP-4702974-A1 | OPHTHALMIC COMPOSITION CONTAINING VVN001 | Vivavision Biotech Ltd. (CN) | 2026-03-04 | — | — | EP | claimed |
| EP-4702973-A1 | OPHTHALMIC COMPOSITION FOR TREATING NON-INFECTIOUS INFLAMMATORY DISEASES | Vivavision Biotech Ltd. (CN) | 2026-03-04 | — | — | EP | claimed |
| CN-119008916-B | Sodium iron pyrophosphate phosphate positive electrode material and preparation method thereof | 湖南美特新材料科技有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-120195312-A | Naringin pollutant analysis and detection method based on high-throughput qualitative analysis | 华南农业大学 | 2025-06-24 | — | — | CN | claimed |
| EP-4552635-A1 | AGENT FOR IMPROVING WELL-BEING AFTER HIGH ALCOHOL CONSUMPTION | Vill, Katharina (DE) | 2025-05-14 | — | — | EP | claimed |
| CN-119827678-A | Detection method for simultaneously detecting various pesticide residues in apples based on QuEChERS-UPLC-MS/MS and application | 青岛农业大学 | 2025-04-15 | — | — | CN | claimed |
| CN-119812262-A | Sodium iron pyrophosphate composite positive electrode material and preparation method thereof | 武汉市理工强钠新能源科技有限责任公司 | 2025-04-11 | — | — | CN | claimed |
| WO-1996007408-A1 | PHARMACEUTICAL FORMULATIONS COMPRISING CLAVULANIC ACID OR DERIVATIVES AND AN ORGANIC ACID OR SALT | SMITHKLINE BEECHAM PLC (GB) | 1996-03-14 | — | — | WO | claimed |
| EP-0188313-B1 | ORAL HYGIENE COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1993-07-14 | — | — | EP | claimed |
| EP-0221699-B1 | COMPOSITION FOR THE TREATMENT OF INFECTIONS | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | claimed |
| US-4824664-A | ANTIHISTAMINES | LABORATOIRES SMITH KLINE & FRENCH (FR) | 1989-04-25 | — | — | US | claimed |
| EP-0221699-A1 | Composition for the treatment of infections | BEECHAM GROUP PLC (GB) | 1987-05-13 | — | — | EP | claimed |
| EP-0188313-A2 | Oral hygiene compositions | BEECHAM GROUP PLC (GB) | 1986-07-23 | — | — | EP | claimed |
| EP-0011489-B1 | AN ANALGESIC EFFERVESCENT POWDER AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | claimed |
| US-4309408-A | ACETAMINOPHEN AND METOCLOPRAMIDE; ANALGESIC FOR MIGRAINE HEADACHES | BEECHAM GROUP LIMITED (GB) | 1982-01-05 | — | — | US | claimed |
| US-4268694-A | HYDROLYSIS OF TETRAHALOCYCLOHEXANONE | FISONS LIMITED (GB) | 1981-05-19 | — | — | US | claimed |
| EP-0011489-A1 | An analgesic effervescent powder and process for its preparation | BEECHAM GROUP PLC (GB) | 1980-05-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260060973-A1 | Ophthalmic Composition for Treating Non-Infectious Inflammatory Diseases | JAK1, TYK2, JAK3 | CA4 3086/4885CASP1 877/4885FFAR3 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.