Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5471628 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL379041 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5191823 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL2867085 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL7519368 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL379089 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL378980 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569395 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569386 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5077427 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2169 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260014178-A1 | COMPOSITIONS AND USES THEREOF | OPTIBIOTIX LTD (GB) | 2026-01-15 | — | — | US | claimed |
| US-12503713-B1 | Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables | Convergent Health Sciences LLC (US) | 2025-12-23 | — | — | US | claimed |
| US-12497637-B1 | Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables | Convergent Health Sciences LLC (US) | 2025-12-16 | — | — | US | claimed |
| US-20250312297-A1 | REDUCTION OF HEALTHCARE RESOURCE UTILIZATION BY PATIENTS TREATED WITH INTRANASALLY-ADMINISTERED METOCLOPRAMIDE | EVOKE PHARMA, INC. | 2025-10-09 | — | — | US | claimed |
| US-20250302777-A1 | METHODS FOR TREATING GASTROPARESIS | EVOKE PHARMA, INC. | 2025-10-02 | — | — | US | claimed |
| CN-120076460-A | Preparation method of optical chip with graphene as substrate and optical chip | 无锡学院 | 2025-05-30 | — | — | CN | claimed |
| EP-4447714-B1 | NICOTINE TABLET | FERTIN PHARMA AS (DK) | 2025-05-14 | — | — | EP | claimed |
| EP-4551042-A1 | COMPOSITIONS AND USES THEREOF | Optibiotix Limited (GB) | 2025-05-14 | — | — | EP | claimed |
| CN-119969579-A | Poria cocos, ginseng and licorice root fermented primary pulp and preparation method thereof | 淮安拾花玖草生物科技有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119564822-A | Peptide-containing composition for improving immunity of human body and preparation method thereof | 兰州百源基因技术有限公司 | 2025-03-07 | — | — | CN | claimed |
| EP-0226332-B1 | VETERINARY COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1992-03-25 | — | — | EP | claimed |
| US-5026539-A | Source of hydrogen citrate ions, oxalate salt, no fluoride anticaries agent | BEECHAM GROUP P.L.C. (GB) | 1991-06-25 | — | — | US | claimed |
| US-5008248-A | Monosaccharide, amino acid and citrate salt mixture | BEECHAM GROUP P.L.C. (GB) | 1991-04-16 | — | — | US | claimed |
| EP-0390457-A1 | Oral hygiene compositions | Beecham Group p.l.c. (GB) | 1990-10-03 | — | — | EP | claimed |
| US-4885279-A | ANTIINFLAMMATORY AGENTS; PREVENTING DAMAGE FROM DRUG USE | RAINSFORD KIM D (GB) | 1989-12-05 | — | — | US | claimed |
| EP-0226332-A1 | Veterinary compositions | BEECHAM GROUP PLC (GB) | 1987-06-24 | — | — | EP | claimed |
| EP-0188313-A2 | Oral hygiene compositions | BEECHAM GROUP PLC (GB) | 1986-07-23 | — | — | EP | claimed |
| US-4324775-A | SCRUBBING WITH ALKALI METAL SALT OF DIVALENT ANION, ION EXCHANGING WITH AMINE SALT | TUNG SHAO E | 1982-04-13 | — | — | US | claimed |
| US-4295982-A | PRODUCT FROM SULFUR, AMINOGUANIDINE, UNSATURATED ACID; CORROSION RESISTANCE | MOBIL OIL CORPORATION (US) | 1981-10-20 | — | — | US | claimed |
| US-4268694-A | HYDROLYSIS OF TETRAHALOCYCLOHEXANONE | FISONS LIMITED (GB) | 1981-05-19 | — | — | US | claimed |