Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230945 | 0.79 | PDE4D (0.64) | PDE4DIDO1PDE4APDE4BPDE4C | |
| SCHEMBL7230440 | 0.78 | PDE4D (0.60) | PDE4DIDO1PDE4APDE4BPDE4C | |
| SCHEMBL28134363 | 0.77 | PDE4D (0.58) | PDE4DIDO1PDE4APDE4CMAPT | |
| SCHEMBL30469329 | 0.75 | PDE4D (0.49) | PDE4DIDO1PDE4BPOLBMAPT | |
| SCHEMBL20557352 | 0.75 | PDE4D (0.49) | PDE4DIDO1PDE4BPOLBMAPT | |
| SCHEMBL3804510 | 0.73 | ALDH1A1 (0.48) | PDE4DPDE4BMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7230510 | 0.73 | NFE2L2 (0.58) | PDE4DIDO1MAPTACHE | |
| SCHEMBL9820237 | 0.73 | PDE4D (0.52) | PDE4DIDO1MAPTALDH1A1THRB | |
| SCHEMBL6852842 | 0.72 | IDO1 (0.50) | PDE4DIDO1PDE4APDE4BMAPT | |
| SCHEMBL22347901 | 0.72 | PLK1 (0.57) | PDE4DIDO1PDE4BPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |