Known targets — ChEMBL curated mechanism
S1PR1S1PR2S1PR3S1PR4S1PR5rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrogen Sulfide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.57 |
| ▸ | CA2 | P00918 | 10/20 | 0.57 |
| ▸ | CA9 | Q16790 | 8/20 | 0.57 |
| ▸ | CA12 | O43570 | 3/20 | 0.57 |
| ▸ | CA7 | P43166 | 3/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.57 |
| ▸ | CA3 | P07451 | 2/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.57 |
| ▸ | CA6 | P23280 | 2/20 | 0.57 |
| ▸ | CA5A | P35218 | 2/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960355 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL247474 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL8488970 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Hydrogen Sulfide SCHEMBL1900178 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL50894 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL25262174 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL16586306 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL22579033 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Tetradecane SCHEMBL21048975 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL1701338 | 0.98 | CA1 (0.59) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871707-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-10-28 | — | — | US | claimed |
| US-11759479-B2 | Compositions comprising a manganese mineral and methods of use | Ohm Creations, LLC (US) | 2023-09-19 | — | — | US | disclosed |
| US-20220313732-A1 | COMPOSITIONS COMPRISING A MANGANESE MINERAL AND METHODS OF USE | Ohm Creations, LLC | 2022-10-06 | — | — | US | disclosed |
| US-20210277072-A1 | PLANT-DERIVED ELASTIN BINDING PROTEIN LIGANDS AND METHODS OF USING THE SAME | ELASTOGENESIS, LLC (US) | 2021-09-09 | — | — | US | disclosed |
| US-10844101-B2 | Plant-derived elastin binding protein ligands and methods of using the same | ELASTOGENESIS, LLC (US) | 2020-11-24 | — | — | US | disclosed |
| US-20190153045-A1 | PLANT-DERIVED ELASTIN BINDING PROTEIN LIGANDS AND METHODS OF USING THE SAME | HUMAN MATRIX SCIENCES, LLC (US) | 2019-05-23 | — | — | US | disclosed |
| US-10167325-B2 | Plant-derived elastin binding protein ligands and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170002047-A1 | PLANT-DERIVED ELASTIN BINDING PROTEIN LIGANDS AND METHODS OF USING THE SAME | HUMAN MATRIX SCIENCES, LLC (US) | 2017-01-05 | — | — | US | disclosed |
| US-9422334-B2 | Plant-derived elastin binding protein ligands and methods of using the same | THE HOSPITAL FOR SICK CHILDREN (CA) | 2016-08-23 | — | — | US | disclosed |
| EP-2460815-B1 | Plant-derived elastin binding protein ligands and their uses | HUMAN MATRIX SCIENCES LLC (US) | 2015-06-03 | — | — | EP | disclosed |
| US-7723308-B2 | Plant-derived elastin binding protein ligands and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2010-05-25 | — | — | US | disclosed |
| US-7666829-B2 | contains manganese chloride, manganese sulfate or manganese nitrate and ferric ammonium citrate or ferric chloride, for treating skin disorders; stimulating production of insoluble elastin, or deposition of collagen, fibroblasts; improve the appearance of scar; wrinkle resistance | HUMAN MATRIX SCIENCES, LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090082280-A1 | Plant-derived elastin binding protein ligands and methods of using the same | NULASTIN, INC. | 2009-03-26 | — | — | US | disclosed |
| US-20080050346-A1 | Elastin producing fibroblast formulations and methods of using the same | NULASTIN, INC. | 2008-02-28 | — | — | US | disclosed |
| EP-1877079-A2 | PLANT-DERIVED ELASTIN BINDING PROTEIN LIGANDS AND METHODS OF USING THE SAME | Human Matrix Sciences, LLC (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1725245-A2 | MANGANESE AND IRON BASED COMPOUNDS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT | Human Matrix Sciences, LLC (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2006125049-A2 | ELASTIN PRODUCING FIBROBLASTS | HUMAN MATRIX SCIENCES, LLC (US) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006113681-A2 | PLANT-DERIVED ELASTIN BINDING PROTEIN LIGANDS AND METHODS OF USING THE SAME | HUMAN MATRIX SCIENCES, LLC (US) | 2006-10-26 | — | — | WO | disclosed |
| US-20050208150-A1 | Compositions for elastrogenesis and connective tissue treatment | NULASTIN, INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005082386-A2 | MANGANESE AND IRON BASED COMPOUNDS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT | HUMAN MATRIX SCIENCES, LLC (US) | 2005-09-09 | — | — | WO | disclosed |