Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794531 | 0.90 | ROCK2 (0.47) | ROCK2ROCK1EPHX2PPARGCYP2C9 | |
| SCHEMBL3786977 | 0.89 | EPHX2 (0.47) | ROCK2ROCK1EPHX2DDR1 | |
| SCHEMBL3808163 | 0.87 | DDR1 (0.45) | ROCK2ROCK1EPHX2DDR1 | |
| SCHEMBL3795177 | 0.86 | DDR1 (0.43) | ROCK2ROCK1EPHX2DDR1 | |
| SCHEMBL3785014 | 0.86 | DDR1 (0.46) | DDR1 | |
| SCHEMBL13257972 | 0.85 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL13258575 | 0.83 | DDR1 (0.41) | ROCK2ROCK1EPHX2DDR1 | |
| SCHEMBL13258576 | 0.83 | DDR1 (0.41) | ROCK2ROCK1EPHX2DDR1 | |
| SCHEMBL3792501 | 0.82 | CNR2 (0.48) | ROCK2ROCK1EPHX2PPARGRIPK1 | |
| SCHEMBL3794154 | 0.82 | EPHX2 (0.52) | ROCK2ROCK1EPHX2PPARGRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |