Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | IKBKB | O14920 | 1/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.68 |
| ▸ | PRKCG | P05129 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1183049 | 0.82 | PLK1 (0.55) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL1321961 | 0.81 | AURKA (1.00) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL4426737 | 0.81 | AURKA (0.69) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL29866211 | 0.81 | AURKA (0.54) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL28405713 | 0.81 | AURKA (0.54) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL440486 | 0.81 | AURKA (1.00) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL657412 | 0.80 | MAPK1 (0.62) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL14024356 | 0.80 | KDR (0.66) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL31337029 | 0.80 | SCN9A (0.82) | NPC1RAB9AKDRSCN9AKCNH2 | |
| SCHEMBL14380911 | 0.80 | IGF1R (0.74) | AURKANPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118279-B1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME | IPINTL LLC (US) | 2017-11-22 | — | — | EP | disclosed |
| EP-2702988-A2 | Novel compositions and methods for treating hyperproliferative diseases | Chen, Chien-Hung (US) | 2014-03-05 | — | — | EP | disclosed |
| US-8486922-B2 | Composition | CHEN CHIEN-HUNG (TW) | 2013-07-16 | — | — | US | disclosed |
| US-8431552-B2 | first agent is an oxidative phosphorylation inhibitor (metformin) or an ionophore or an adenosine 5'-monophosphate-activated Protein kinase (AMPK) activator; second agent is antiinflammatory agent; and an third agent that possesses serotonin activity | CHEN CHIEN-HUNG (US) | 2013-04-30 | — | — | US | disclosed |
| US-8377947-B2 | Treating alzheimer's disease and osteoporosis and reducing aging | CHEN CHIEN-HUNG (US) | 2013-02-19 | — | — | US | disclosed |
| US-8367645-B2 | Compositions and methods for treating hyperproliferative diseases | CHEN CHIEN-HUNG (US) | 2013-02-05 | — | — | US | disclosed |
| EP-2494967-A1 | Novel composition for treating metabolic syndrome | IPINTL, LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | disclosed |
| EP-2408434-A1 | TREATING ALZHEIMER'S DISEASE AND OSTEOPOROSIS AND REDUCING AGING | IPINTL, LLC (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20110281829-A1 | NOVEL COMPOSITION | IPINTL, LLC (US) | 2011-11-17 | — | — | US | disclosed |
| WO-2010107702-A1 | TREATING ALZHEIMER'S DISEASE AND OSTEOPOROSIS AND REDUCING AGING | IPINTL, LLC (US) | 2010-09-23 | — | — | WO | disclosed |
| US-20100234295-A1 | Treating Alzheimer's Disease And Osteoporosis And Reducing Aging | CHEN CHIEN-HUNG | 2010-09-16 | — | — | US | disclosed |
| EP-2123267-A1 | Novel compositions and methods for treating hyperproliferative diseases | Chen, Chien-Hung (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090286760-A1 | Novel Compositions and Methods for Treating Hyperproliferative Diseases | CHEN CHIEN-HUNG | 2009-11-19 | — | — | US | disclosed |
| WO-2009140680-A1 | NOVEL COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASES | ALS MOUNTAIN LLC (US) | 2009-11-19 | — | — | WO | disclosed |
| EP-2118279-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME | IPINTL, LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008089212-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME | IPINTL, LLC (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20080176822-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME | CHEN CHIEN-HUNG | 2008-07-24 | — | — | US | disclosed |