Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | IKBKB | O14920 | 1/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.68 |
| ▸ | PRKCG | P05129 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321961 | 0.81 | AURKA (1.00) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL379222 | 0.81 | AURKA (0.69) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL440486 | 0.81 | AURKA (1.00) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL31337079 | 0.80 | ROCK1 (0.69) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL5263722 | 0.80 | PIK3CA (0.48) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL1120994 | 0.78 | PIK3CG (0.51) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL23887662 | 0.77 | KDR (0.47) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL30086805 | 0.77 | KDR (0.47) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL5384269 | 0.76 | AURKA (0.87) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL4621303 | 0.76 | NPC1 (0.87) | AURKANPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648524-B1 | USE OF SUBSTITUTED 2,4-BIS (ALKYLAMINO) PYRIMIDINES OR -QUINAZOLINES AS ANTIMICROBIALS | CIBA HOLDING INC (CH) | 2009-01-14 | — | — | EP | disclosed |