Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908110 | 0.78 | HTT (0.46) | HPGDNPC1ALDH1A1MMEKMT2A | |
| SCHEMBL378420 | 0.76 | TACR1 (0.48) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL378386 | 0.73 | TACR1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL378394 | 0.72 | TAAR1 (0.51) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2471162 | 0.70 | TSHR (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1TAAR1 | |
| SCHEMBL13092158 | 0.70 | HTT (0.48) | HPGDNPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13593941 | 0.70 | TACR1 (0.45) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL658361 | 0.70 | KDM4E (0.70) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31682182 | 0.69 | SSTR4 (0.39) | TAAR1 | |
| SCHEMBL5081412 | 0.68 | KMT2A (0.59) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408745-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-01-25 | — | — | EP | disclosed |