Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623513 | 1.00 | GRIN2B (0.41) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL8528362 | 0.95 | GRIN2B (0.45) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL16009191 | 0.83 | CTSK (0.42) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL28832612 | 0.81 | GRIN2B (0.40) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL2981422 | 0.81 | JAK3 (0.48) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL20054323 | 0.81 | GRIN2B (0.43) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL29619416 | 0.81 | GRIN2B (0.40) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL27973224 | 0.81 | GRIN2B (0.40) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL29073248 | 0.80 | GRIN2B (0.39) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL3266727 | 0.80 | GRIN2B (0.39) | GRIN2BGRIN2CJAK3HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |
| CN-100448874-C | N-aroyl cyclic amines | SMITHKLINE BEECHAM PLC (GB) | 2009-01-07 | — | — | CN | disclosed |
| CN-1633433-A | N-aroyl cyclic amines | SMITHKLINE BEECHAM PLC (GB) | 2005-06-29 | — | — | CN | disclosed |