Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | MGLL | Q99685 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13227911 | 0.98 | GNAI3 (0.37) | GNAI3GNAO1GNAI1KDM4EGAA | |
| SCHEMBL4058237 | 0.72 | GNAI3 (0.38) | GNAI3GNAO1GNAI1GAAGBA1 | |
| SCHEMBL4062055 | 0.72 | GNAI3 (0.38) | GNAI3GNAO1GNAI1GAAGBA1 | |
| SCHEMBL4234739 | 0.72 | GNAI3 (0.38) | GNAI3GNAO1GNAI1GAAGBA1 | |
| SCHEMBL4066563 | 0.72 | GNAI3 (0.38) | GNAI3GNAO1GNAI1GAAGBA1 | |
| SCHEMBL411687 | 0.72 | GNAI3 (0.38) | GNAI3GNAO1GNAI1GAAGBA1 | |
| Bromide SCHEMBL11538259 | 0.71 | ALDH1A1 (0.38) | GNAI3GNAO1GNAI1KDM4EGAA | |
| SCHEMBL31426987 | 0.69 | GBA1 (0.39) | GNAI3GNAO1GNAI1GBA1EEF2K | |
| SCHEMBL31426994 | 0.69 | GBA1 (0.39) | GNAI3GNAO1GNAI1GBA1EEF2K | |
| SCHEMBL21049617 | 0.67 | CDC25A (0.51) | KDM4ELMNAHTTEEF2KALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210616-A1 | METAL COMPLEXES INCORPORATED WITHIN BIODEGRADABLE NANOPARTICLES AND THEIR USE | THE UNIVERSITY OF AKRON (US) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210616-A1 | METAL COMPLEXES INCORPORATED WITHIN BIODEGRADABLE NANOPARTICLES AND THEIR USE | ALG1, CD68, MAN2B1 | GNAI3 1571/4885GNAO1 3663/4885GNAI1 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.