Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788606 | 0.79 | MYC (0.35) | ALDH1A1TP53NT5EPLAUR | |
| SCHEMBL519309 | 0.75 | PDE10A (0.53) | ALDH1A1MAPK1HSD17B10L3MBTL1CYP2C9 | |
| SCHEMBL7591549 | 0.68 | L3MBTL1 (0.64) | ALDH1A1MAPK1HSD17B10L3MBTL1MMP2 | |
| SCHEMBL31448310 | 0.68 | L3MBTL1 (0.64) | ALDH1A1MAPK1HSD17B10L3MBTL1MMP2 | |
| SCHEMBL27963536 | 0.65 | PDE10A (0.46) | ALDH1A1NPSR1NT5E | |
| SCHEMBL3793536 | 0.64 | MAPT (0.43) | L3MBTL1TP53NT5EMAPT | |
| SCHEMBL3788317 | 0.63 | NPBWR1 (0.45) | ALDH1A1HSD17B10CYP2C9NPSR1NT5E | |
| SCHEMBL22494203 | 0.62 | L3MBTL1 (0.72) | ALDH1A1MAPK1HSD17B10L3MBTL1NPSR1 | |
| SCHEMBL2496328 | 0.61 | KDM4E (0.34) | ALDH1A1NT5EMAPT | |
| SCHEMBL27963560 | 0.61 | PDE10A (0.46) | ALDH1A1NPSR1NT5EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393360-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090737-A1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-12 | — | — | WO | disclosed |