Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1671236 | 0.86 | AR (0.47) | KDM4EALDH1A1HDAC1HDAC6AR | |
| SCHEMBL3789909 | 0.86 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2HDAC1HDAC6LMNA | |
| SCHEMBL31167486 | 0.83 | PTGER3 (0.43) | ARLMNAMAPTHTTBLM | |
| SCHEMBL28238549 | 0.77 | HDAC1 (0.56) | POLBHDAC1HDAC6ARCYP2D6 | |
| SCHEMBL10228321 | 0.77 | PTGER3 (0.43) | SMN1; SMN2ARMAPTCYP2D6 | |
| SCHEMBL10228536 | 0.77 | CYP2D6 (0.39) | SMN1; SMN2HDAC1HDAC6SLC5A1SLC5A2 | |
| SCHEMBL3793050 | 0.76 | HTR2A (0.56) | POLBKDM4EALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL1670063 | 0.75 | CYP2D6 (0.40) | HDAC1HDAC6SLC5A2ARLMNA | |
| SCHEMBL21941375 | 0.75 | RORC (0.40) | AR | |
| SCHEMBL1669951 | 0.74 | AR (0.38) | KDM4EALDH1A1SMN1; SMN2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010128152-A1 | FUSED HETEROCYCLIC C-GLYCOSIDES FOR THE TREATMENT OF DIABETES | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | disclosed |