SCHEMBL28238549

SCHEMBL28238549

Brc1ccc(CN2CCOc3ccccc32)cc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
TSHR P16473 5/20 0.49
KMT2A Q03164 1/20 0.48
HPGD P15428 1/20 0.46
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43
PTGDR2 Q9Y5Y4 1/20 0.43
CYP2D6 P10635 1/20 0.42
GRM5 P41594 1/20 0.41
AR P10275 1/20 0.41
NOTUM Q6P988 1/20 0.41
HTR1A P08908 1/20 0.41
SLC6A4 P31645 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9147970 0.87 TSHR (0.58) HDAC1HDAC6TSHRKMT2AHPGD
SCHEMBL8554596 0.85 HDAC1 (0.53) HDAC1HDAC6TSHRKMT2AHPGD
SCHEMBL2208731 0.85 HDAC1 (0.53) HDAC1HDAC6TSHRKMT2AHPGD
SCHEMBL1671236 0.82 AR (0.47) HDAC1HDAC6TSHRKMT2ADRD2
SCHEMBL5739046 0.81 L3MBTL1 (0.57) HDAC1HDAC6TSHRKMT2AHTR1A
SCHEMBL24499948 0.81 HDAC1 (0.45) HDAC1HDAC6TSHRKMT2AHPGD
SCHEMBL29598378 0.81 HDAC1 (0.45) HDAC1HDAC6TSHRKMT2AHPGD
SCHEMBL2211793 0.79 SIRT2 (0.59) HDAC1HDAC6TSHRKMT2AHPGD
SCHEMBL12388072 0.79 LMNA (0.52) HDAC1HDAC6TSHRKMT2ACYP2D6
SCHEMBL3793471 0.77 POLB (0.44) HDAC1HDAC6CYP2D6ARPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108431007-A PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER 洛克索肿瘤学股份有限公司 2018-08-21 CN disclosed