Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790506 | 0.86 | HDAC3 (0.49) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3786230 | 0.85 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3793731 | 0.85 | SMYD2 (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL30350303 | 0.83 | PARP1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL28074486 | 0.83 | PARP1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3714557 | 0.82 | HDAC3 (0.47) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3714232 | 0.76 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL30077555 | 0.76 | EZH2 (0.72) | — | |
| SCHEMBL3787392 | 0.76 | BTK (0.45) | MMP2MMP8MMP13JAK2 | |
| SCHEMBL3785950 | 0.76 | KCNH2 (0.46) | MMP2MMP8MMP13JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |