Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790506 | 0.89 | HDAC3 (0.49) | BTKMMP2MMP8MMP13 | |
| SCHEMBL3713512 | 0.82 | TBK1 (0.43) | MAPK1SMN1; SMN2HCRTR1HCRTR2MMP2 | |
| SCHEMBL13188477 | 0.79 | HDAC1 (0.48) | MAPK1SMN1; SMN2HCRTR1HCRTR2MMP2 | |
| SCHEMBL3712170 | 0.77 | MAPK1 (0.52) | MAPK1SMN1; SMN2MMP2MMP8MMP13 | |
| SCHEMBL13188593 | 0.76 | SMYD2 (0.46) | BTKMAPK1SMN1; SMN2JAK2 | |
| SCHEMBL3793952 | 0.76 | HDAC1 (0.49) | JAK2MMP2MMP8MMP13 | |
| SCHEMBL3720699 | 0.76 | MAPK1 (0.47) | MAPK1SMN1; SMN2MMP2MMP8MMP13 | |
| SCHEMBL26094981 | 0.75 | HCRTR1 (0.53) | MAPK1SMN1; SMN2HCRTR1HCRTR2MMP2 | |
| SCHEMBL3785950 | 0.75 | KCNH2 (0.46) | BTKJAK2MMP2MMP8MMP13 | |
| SCHEMBL254974 | 0.74 | MAPK1 (0.70) | MAPK1SMN1; SMN2MMP2MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |