Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793731 | 0.91 | SMYD2 (0.48) | KCNH2JAK2SMYD2MMP2MMP8 | |
| SCHEMBL13188593 | 0.88 | SMYD2 (0.46) | KCNH2JAK2SMYD2ACP1BTK | |
| SCHEMBL3793389 | 0.82 | KCNH2 (0.42) | KCNH2JAK2SMYD2MMP2MMP8 | |
| SCHEMBL15905202 | 0.76 | KCNH2 (0.52) | KCNH2JAK2ACP1MOK | |
| SCHEMBL3709419 | 0.76 | PARP1 (0.45) | MMP2MMP8MMP13 | |
| SCHEMBL3790506 | 0.76 | HDAC3 (0.49) | MMP2MMP8MMP13BTK | |
| SCHEMBL3793952 | 0.76 | HDAC1 (0.49) | JAK2MMP2MMP8MMP13 | |
| SCHEMBL3721164 | 0.75 | PARP1 (0.47) | KCNH2JAK2MMP2MMP8MMP13 | |
| SCHEMBL3787392 | 0.75 | BTK (0.45) | JAK2MMP2MMP8MMP13BTK | |
| SCHEMBL15322940 | 0.74 | KCNH2 (0.73) | KCNH2JAK2DHODHMOK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |