Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 3/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795969 | 0.84 | PTGES (0.56) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3792228 | 0.81 | PTGES (0.39) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3790901 | 0.70 | PTGES (0.39) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3792008 | 0.70 | PTGES (0.62) | PTGESJAK2TTR | |
| SCHEMBL3177289 | 0.70 | NR4A2 (0.58) | PTGESMAPTTDP1TP53POLB | |
| SCHEMBL2360771 | 0.70 | PTGES (0.50) | PTGESJAK2TTR | |
| SCHEMBL4356662 | 0.67 | PTGES (0.82) | PTGESJAK2 | |
| SCHEMBL3797090 | 0.66 | RHEB (0.41) | PTGESMAPTTP53 | |
| SCHEMBL2361133 | 0.66 | PTGES (0.53) | PTGESJAK2TTR | |
| SCHEMBL3801705 | 0.65 | PTGES (0.58) | PTGESJAK2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |