Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797090 | 0.93 | RHEB (0.41) | PTGESAPPMAPK14RHEBNPC1 | |
| SCHEMBL3798547 | 0.93 | PTGES (0.39) | PTGESAPPMAPK14RHEBNPC1 | |
| SCHEMBL3792228 | 0.89 | PTGES (0.39) | PTGESAPPPIM1CSNK2A2CSNK2B | |
| SCHEMBL4784907 | 0.81 | RHEB (0.46) | PTGESMAPK14RHEBNPC1RAB9A | |
| SCHEMBL3800146 | 0.80 | PIM1 (0.49) | PTGESNPC1RAB9APIM1CSNK2A2 | |
| SCHEMBL3796734 | 0.79 | PTGES (0.43) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3795502 | 0.79 | PTGES (0.43) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3802320 | 0.78 | PTGES (0.40) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3791130 | 0.77 | PTGES (0.42) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3796208 | 0.76 | PTGES (0.48) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |