Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797555 | 1.00 | PDE4D (0.38) | PDE4DABL1PDE4BSMN1; SMN2USP2 | |
| SCHEMBL3796371 | 1.00 | PDE4D (0.38) | PDE4DABL1PDE4BSMN1; SMN2USP2 | |
| Hydrochloric Acid SCHEMBL3792955 | 0.99 | PDE4D (0.38) | PDE4DABL1PDE4BSMN1; SMN2USP2 | |
| Hydrochloric Acid SCHEMBL3790310 | 0.99 | PDE4D (0.38) | PDE4DABL1PDE4BSMN1; SMN2USP2 | |
| SCHEMBL3796900 | 0.96 | GID4 (0.41) | PDE4DABL1PDE4BSMN1; SMN2USP2 | |
| SCHEMBL3467149 | 0.86 | PDE4D (0.43) | PDE4DPDE4BSMN1; SMN2LMNARAB9A | |
| SCHEMBL7904591 | 0.85 | PDE4D (0.51) | PDE4DPDE4BSMN1; SMN2LMNARAB9A | |
| SCHEMBL8031130 | 0.83 | MAPK1 (0.42) | PDE4DABL1MEN1KMT2A | |
| SCHEMBL11996275 | 0.82 | PDE4D (0.40) | PDE4DSMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL4323934 | 0.82 | CYP1A2 (0.45) | PDE4DSMN1; SMN2RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |