Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.70 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | STAT6 | P42226 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.49 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716065 | 0.92 | TBK1 (0.62) | TBK1JAK3STAT6CDK1KDR | |
| SCHEMBL3714974 | 0.91 | TBK1 (0.61) | TBK1JAK3STAT6CDK1KDR | |
| SCHEMBL3795187 | 0.87 | TBK1 (0.70) | TBK1JAK3STAT6CDK1KDR | |
| SCHEMBL3711061 | 0.86 | STAT6 (0.55) | TBK1JAK3STAT6CDK2JAK2 | |
| SCHEMBL15163250 | 0.84 | TBK1 (0.82) | TBK1JAK3STAT6CDK1KDR | |
| SCHEMBL1284578 | 0.82 | TBK1 (1.00) | TBK1JAK3STAT6CDK1KDR | |
| SCHEMBL3711046 | 0.81 | JAK3 (0.53) | TBK1JAK3KDRTYK2JAK2 | |
| SCHEMBL3790567 | 0.81 | STAT6 (0.65) | JAK3STAT6CDK1CDK2AURKA | |
| SCHEMBL15163477 | 0.80 | CDK4 (0.53) | TBK1JAK3STAT6CDK1KDR | |
| SCHEMBL3717362 | 0.79 | STAT6 (0.53) | TBK1JAK3STAT6CSF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |