Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 15/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796734 | 1.00 | PTGES (0.43) | PTGESJAK2FFAR1PIM1CSNK2A2 | |
| SCHEMBL3791130 | 0.89 | PTGES (0.42) | PTGESJAK2PIM1CSNK2A2CSNK2B | |
| SCHEMBL3802320 | 0.89 | PTGES (0.40) | PTGESJAK2FFAR1PIM1CSNK2A2 | |
| SCHEMBL3798195 | 0.87 | FFAR1 (0.37) | PTGESFFAR1PIM1CSNK2A2CSNK2B | |
| SCHEMBL3797090 | 0.85 | RHEB (0.41) | PTGESPTGS1 | |
| SCHEMBL3800146 | 0.85 | PIM1 (0.49) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3796208 | 0.85 | PTGES (0.48) | PTGESPTGS1 | |
| SCHEMBL3792228 | 0.84 | PTGES (0.39) | PTGESFFAR1PIM1CSNK2A2CSNK2B | |
| SCHEMBL3803252 | 0.84 | MAPT (0.39) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL3791956 | 0.82 | PIM1 (0.35) | PTGESFFAR1PIM1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |