Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 20/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795502 | 0.85 | PTGES (0.43) | PTGESPTGS1 | |
| SCHEMBL3796734 | 0.85 | PTGES (0.43) | PTGESPTGS1 | |
| SCHEMBL3800146 | 0.83 | PIM1 (0.49) | PTGES | |
| SCHEMBL3796752 | 0.82 | PTGES (0.62) | PTGESPTGS1PTGS2 | |
| SCHEMBL3792228 | 0.81 | PTGES (0.39) | PTGES | |
| SCHEMBL3802320 | 0.78 | PTGES (0.40) | PTGESPTGS1 | |
| SCHEMBL3791130 | 0.77 | PTGES (0.42) | PTGESPTGS1 | |
| SCHEMBL3790901 | 0.76 | PTGES (0.39) | PTGES | |
| SCHEMBL3796674 | 0.76 | PTGES (0.67) | PTGES | |
| SCHEMBL3803252 | 0.76 | MAPT (0.39) | PTGESPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |