Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796469 | 0.80 | POLB (0.52) | BACE1TLR8POLBMEN1KMT2A | |
| SCHEMBL19437515 | 0.76 | KMT2A (0.63) | TLR8POLBKMT2A | |
| SCHEMBL3795628 | 0.74 | POLB (0.51) | BACE1TLR8POLBNUDT1 | |
| SCHEMBL29154781 | 0.72 | TLR8 (0.65) | BACE1TLR8ADORA2AASAH1NUDT1 | |
| SCHEMBL2875385 | 0.72 | CNR2 (0.49) | — | |
| SCHEMBL21307563 | 0.72 | POLB (0.62) | BACE1TLR8POLBKMT2AKDM4E | |
| SCHEMBL3798908 | 0.72 | POLB (0.51) | BACE1TLR8POLBNUDT1 | |
| SCHEMBL3729395 | 0.71 | CNR2 (0.48) | — | |
| SCHEMBL19553580 | 0.71 | NPC1 (0.54) | POLBMEN1KMT2AKDM4EHPGD | |
| SCHEMBL21409102 | 0.71 | POLB (0.57) | POLBMEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |