Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077024 | 0.83 | ACSS2 (0.48) | POLBTLR8RAB9ACYP1A2CYP2C19 | |
| SCHEMBL21437408 | 0.82 | BACE1 (0.53) | POLBTLR8BACE1MAPTNUDT1 | |
| SCHEMBL3795623 | 0.80 | BACE1 (0.51) | POLBTLR8CYP1A2CYP2C19BACE1 | |
| SCHEMBL3799520 | 0.80 | ACSS2 (0.53) | POLBTLR8RAB9ANPC1MAPT | |
| SCHEMBL26451909 | 0.78 | HSD17B10 (0.55) | POLBRAB9ACYP1A2NPC1MAPT | |
| SCHEMBL19437515 | 0.77 | KMT2A (0.63) | POLBTLR8NPC1KMT2ASTING1 | |
| Hydrochloric Acid SCHEMBL28512158 | 0.76 | EHMT2 (0.56) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL3795628 | 0.76 | POLB (0.51) | POLBTLR8BACE1NUDT1 | |
| SCHEMBL26451915 | 0.76 | RAB9A (0.54) | POLBTLR8RAB9ANPC1BACE1 | |
| SCHEMBL21437355 | 0.75 | BACE1 (0.53) | TLR8RAB9ANPC1BACE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |