Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.48 |
| ▸ | ITK | Q08881 | 7/20 | 0.44 |
| ▸ | INSR | P06213 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 5/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798908 | 0.90 | POLB (0.51) | POLBTLR8ITKINSRBACE1 | |
| SCHEMBL13076395 | 0.84 | POLB (0.45) | POLBTLR8ITKINSRBACE1 | |
| SCHEMBL3800016 | 0.83 | TLR8 (0.55) | POLBTLR8ITKBACE1NUDT1 | |
| SCHEMBL3797142 | 0.80 | POLB (0.51) | POLBTLR8ITKBACE1ALDH1A1 | |
| SCHEMBL19437515 | 0.76 | KMT2A (0.63) | POLBTLR8 | |
| SCHEMBL3791176 | 0.76 | ITK (0.47) | TLR8ITKINSRBACE1 | |
| SCHEMBL6023368 | 0.76 | ITK (0.74) | ITKINSRTXK | |
| SCHEMBL3796469 | 0.76 | POLB (0.52) | POLBTLR8BACE1NUDT1 | |
| SCHEMBL6416240 | 0.75 | ITK (0.61) | ITKINSRTXK | |
| SCHEMBL6417117 | 0.75 | ITK (0.59) | ITKINSRTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |