Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798908 | 0.90 | POLB (0.51) | POLBTLR8ITKBACE1CNR2 | |
| SCHEMBL3800016 | 0.83 | TLR8 (0.55) | POLBTLR8ITKBACE1CNR2 | |
| SCHEMBL3795628 | 0.80 | POLB (0.51) | POLBTLR8ITKBACE1SMN1; SMN2 | |
| SCHEMBL19437489 | 0.76 | POLB (0.60) | POLBTLR8HTTCYP1A2CYP2D6 | |
| SCHEMBL3791176 | 0.76 | ITK (0.47) | TLR8ITKBACE1CNR2 | |
| SCHEMBL3799520 | 0.76 | ACSS2 (0.53) | POLBTLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL13076395 | 0.75 | POLB (0.45) | POLBTLR8ITKBACE1CNR2 | |
| SCHEMBL13076797 | 0.71 | POLB (0.49) | POLBTLR8SMN1; SMN2ALDH1A1RECQL | |
| SCHEMBL3807243 | 0.70 | ITK (0.42) | ITKBACE1CNR2HTTSMN1; SMN2 | |
| SCHEMBL3795349 | 0.69 | ITK (0.59) | ITKMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |