SCHEMBL379566

SCHEMBL379566

CC(O)Cc1ccc(C#N)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.54
LOXL2 Q9Y4K0 2/20 0.50
HRH3 Q9Y5N1 1/20 0.45
MAOB P27338 1/20 0.43
CTBP2 P56545 1/20 0.43
IDO1 P14902 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CA12 O43570 1/20 0.43
CA2 P00918 1/20 0.43
CA3 P07451 1/20 0.43
CA6 P23280 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
MMP12 P39900 1/20 0.41
MMP13 P45452 1/20 0.41
SAE1 Q9UBE0 1/20 0.41
UBA2 Q9UBT2 1/20 0.41
HTT P42858 1/20 0.41
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19354446 1.00 CYP2A6 (0.54) CYP2A6LOXL2HRH3MAOBCTBP2
SCHEMBL23059553 0.88 ESR1 (0.43) CYP2A6LOXL2HRH3MAOBCTBP2
SCHEMBL19354445 0.84 CYP2A6 (0.50) CYP2A6LOXL2HRH3MAOBCTBP2
SCHEMBL2320821 0.83 CYP2A6 (0.58) CYP2A6LOXL2MAOBIDO1ALDH1A1
SCHEMBL10668261 0.83 LOXL2 (0.52) CYP2A6LOXL2HRH3CTBP2IDO1
SCHEMBL196800 0.82 TAAR1 (0.48) TSHR
SCHEMBL18930746 0.81 LOXL2 (0.47) CYP2A6LOXL2HRH3MAOBIDO1
SCHEMBL1226223 0.81 LOXL2 (0.50) CYP2A6LOXL2HRH3MAOBCTBP2
SCHEMBL10621501 0.80 CYP2A6 (0.55) CYP2A6LOXL2HRH3MAOBIDO1
SCHEMBL9902676 0.80 CYP2A6 (0.50) CYP2A6LOXL2HRH3MAOBCTBP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408777-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI (FR) 2012-01-25 EP claimed
WO-2010107969-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI-AVENTIS (FR) 2010-09-23 WO claimed
EP-2408777-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI (FR) 2012-01-25 EP disclosed
WO-2010107969-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI-AVENTIS (FR) 2010-09-23 WO disclosed