Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10621501 | 0.88 | CYP2A6 (0.55) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL7395294 | 0.85 | LOXL2 (0.42) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL1226223 | 0.84 | LOXL2 (0.50) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL379566 | 0.83 | CYP2A6 (0.54) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL19354446 | 0.83 | CYP2A6 (0.54) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL4084185 | 0.83 | LOXL2 (0.48) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL19143772 | 0.82 | MMP12 (0.43) | LOXL2CYP2A6MMP12MMP13HRH3 | |
| SCHEMBL19354445 | 0.79 | CYP2A6 (0.50) | LOXL2CYP2A6MMP12MMP13CA12 | |
| SCHEMBL92970 | 0.78 | LOXL2 (0.58) | LOXL2CYP2A6CA12CA2CA3 | |
| SCHEMBL6245764 | 0.78 | KDM6B (0.51) | LOXL2CYP2A6MMP12MMP13CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4732907-A | Antiprotozoal diamidines and bis-imidazoline | PFIZER INC. (US) | 1988-03-22 | — | — | US | disclosed |
| US-4624958-A | Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles | PFIZER INC. (US) | 1986-11-25 | — | — | US | disclosed |
| US-4546113-A | Antiprotozoal diamidines | PFIZER INC. (US) | 1985-10-08 | — | — | US | disclosed |