Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 12/20 | 0.53 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | FES | P07332 | 2/20 | 0.47 |
| ▸ | ROS1 | P08922 | 2/20 | 0.47 |
| ▸ | FER | P16591 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800951 | 0.81 | MAP4K4 (0.44) | MAP4K4MKNK2MAP4K5PDGFRBPDGFRA | |
| SCHEMBL4128040 | 0.76 | CDK8 (0.62) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL3795296 | 0.75 | ATM (0.38) | MAP4K4CHEK2ALOX5APFEN1JAK2 | |
| SCHEMBL2079662 | 0.74 | HSP90AB1 (0.66) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL2079173 | 0.73 | CDK8 (0.56) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL3798573 | 0.73 | PDK2 (0.41) | PKN2ALOX5APFEN1 | |
| SCHEMBL2077908 | 0.73 | CDK8 (0.52) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL2077906 | 0.73 | CDK8 (0.52) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL3797695 | 0.72 | CSNK1A1 (0.58) | DYRK1B | |
| SCHEMBL4077067 | 0.72 | CSNK1A1 (0.58) | DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI-AVENTIS (FR) | 2010-05-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | HSP90AB2P, HSPA2, HSP90AB1 | CDK8 3435/4885CDK7 3468/4885CCNT1 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.