Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.80 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.69 |
| ▸ | STAT3 | P40763 | 1/20 | 0.68 |
| ▸ | SYK | P43405 | 1/20 | 0.68 |
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.61 |
| ▸ | GRK2 | P25098 | 1/20 | 0.61 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | EIF4E | P06730 | 1/20 | 0.58 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796210 | 1.00 | ENPP2 (0.80) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL29987110 | 1.00 | ENPP2 (0.80) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL4402019 | 0.89 | ENPP2 (1.00) | ENPP2SYKMAP3K5MEN1KMT2A | |
| SCHEMBL4398637 | 0.89 | ENPP2 (1.00) | ENPP2SYKMAP3K5MEN1KMT2A | |
| SCHEMBL3134450 | 0.87 | TNFRSF1A (0.74) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL3134440 | 0.87 | TNFRSF1A (0.74) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL3134456 | 0.87 | TNFRSF1A (0.74) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL3135786 | 0.84 | TNFRSF1A (0.73) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL3136515 | 0.84 | MAP3K5 (0.76) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 | |
| SCHEMBL3136503 | 0.84 | MAP3K5 (0.76) | ENPP2TNFRSF1ASTAT3SYKMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296270-A1 | STAT3 Inhibitors | BAYLOR COLLEGE OF MEDICINE (US) | 2014-10-02 | — | — | US | claimed |
| US-20100041685-A1 | STAT3 INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041685-A1 | STAT3 INHIBITORS | STAT3, STAT1, JAK2 | ENPP2 2684/4885TNFRSF1A 1007/4885STAT3 1/4885 |
| US-20140296270-A1 | STAT3 Inhibitors | STAT3, STAT1, JAK2 | ENPP2 2684/4885TNFRSF1A 1007/4885STAT3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.