Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 19/20 | 0.73 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.73 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794478 | 0.90 | TRPA1 (0.75) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3810127 | 0.88 | TRPA1 (0.76) | TRPA1TRPV4TRPV3MEN1ALDH1A1 | |
| SCHEMBL3794988 | 0.86 | TRPA1 (0.61) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3791508 | 0.86 | TRPA1 (0.69) | TRPA1TRPV4MEN1MAPTKMT2A | |
| SCHEMBL3794851 | 0.85 | TRPA1 (0.80) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3798206 | 0.85 | TRPA1 (0.76) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3794310 | 0.85 | TRPA1 (0.61) | TRPA1TRPV4TRPV3LMNAMAPT | |
| SCHEMBL612545 | 0.85 | TRPA1 (0.71) | TRPA1TRPV4TRPV3MEN1ALDH1A1 | |
| SCHEMBL1803340 | 0.85 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL12323499 | 0.83 | TRPA1 (0.75) | TRPA1TRPV4TRPV3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | claimed |
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |