Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 18/20 | 0.69 |
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796445 | 0.92 | TRPA1 (0.81) | TRPA1TRPV4 | |
| SCHEMBL3798786 | 0.89 | TRPA1 (0.72) | TRPA1TRPV4 | |
| SCHEMBL3797771 | 0.89 | TRPA1 (0.81) | TRPA1TRPV4 | |
| SCHEMBL3802191 | 0.89 | TRPA1 (0.60) | TRPA1TRPV4MAPT | |
| SCHEMBL3794988 | 0.89 | TRPA1 (0.61) | TRPA1TRPV4 | |
| SCHEMBL3797553 | 0.88 | TRPA1 (0.73) | TRPA1TRPV4 | |
| SCHEMBL3796551 | 0.86 | TRPA1 (0.73) | TRPA1TRPV4MAPTMEN1KMT2A | |
| SCHEMBL1801559 | 0.84 | TRPA1 (0.86) | TRPA1TRPV4 | |
| SCHEMBL612021 | 0.84 | TRPA1 (0.83) | TRPA1TRPV4MAPTMEN1KMT2A | |
| SCHEMBL3799501 | 0.84 | TRPA1 (0.60) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |