Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL10765780 | 0.90 | TDP1 (0.71) | TDP1HSD17B10USP2HTT | |
| SCHEMBL4398781 | 0.88 | TDP1 (0.54) | TDP1HSD17B10ALDH1A1 | |
| Propylene Glycol SCHEMBL28100333 | 0.84 | TDP1 (0.62) | TDP1HSD17B10USP2HTT | |
| SCHEMBL4889303 | 0.84 | TDP1 (0.55) | TDP1HSD17B10 | |
| SCHEMBL26146326 | 0.84 | ALDH1A1 (0.50) | TDP1HSD17B10ALDH1A1HTT | |
| Propylene Glycol SCHEMBL29215792 | 0.82 | TDP1 (0.55) | TDP1HSD17B10USP2 | |
| SCHEMBL5320748 | 0.82 | TDP1 (0.70) | TDP1HSD17B10USP2HTT | |
| Propylene Glycol SCHEMBL28757874 | 0.81 | TDP1 (0.53) | TDP1HSD17B10USP2 | |
| SCHEMBL15290418 | 0.80 | TDP1 (0.74) | TDP1HSD17B10USP2HTT | |
| Propylene Glycol SCHEMBL9452025 | 0.80 | HSD17B10 (0.45) | TDP1HSD17B10USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114899-A1 | SUBSTRATE PRINTED WITH A WATER-BASED URETHANE PRINTING INK WITH IMPROVED PERFORMANCE PROPERTIES | SUN CHEMICAL CORPORATION (US) | 2010-10-07 | — | — | WO | disclosed |