Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 19/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755228 | 0.84 | PTGES (0.57) | PTGESPTGS1PTGS2PIM1CSNK2A2 | |
| SCHEMBL3796208 | 0.82 | PTGES (0.48) | PTGESPTGS1PTGS2 | |
| SCHEMBL3790511 | 0.78 | PTGES (0.78) | PTGESPTGS1PTGS2 | |
| SCHEMBL3795330 | 0.77 | PTGES (1.00) | PTGES | |
| SCHEMBL3801179 | 0.70 | PTGES (0.66) | PTGESPTGS1PIM1CSNK2A2CSNK2B | |
| SCHEMBL3795969 | 0.69 | PTGES (0.56) | PTGESPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL12479262 | 0.69 | PTGES (0.75) | PTGESPTGS1PTGS2 | |
| SCHEMBL3791995 | 0.68 | PTGES (0.53) | PTGES | |
| SCHEMBL13075956 | 0.68 | PTGES (0.53) | PTGES | |
| SCHEMBL3800146 | 0.68 | PIM1 (0.49) | PTGESPIM1CSNK2A2CSNK2BPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |