Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 10/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 3/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792008 | 0.83 | PTGES (0.62) | PTGESJAK2GCGRSCN2AHPGDS | |
| SCHEMBL3799056 | 0.82 | PTGES (0.40) | PTGESJAK2ORAI1GCGR | |
| SCHEMBL3794463 | 0.81 | PTGES (0.67) | PTGESJAK2ORAI1SCN2AHPGDS | |
| SCHEMBL3802423 | 0.81 | PTGES (0.57) | PTGESJAK2GCGR | |
| SCHEMBL3800707 | 0.81 | PTGES (0.60) | PTGESJAK2GCGR | |
| SCHEMBL3796557 | 0.80 | PTGES (0.53) | PTGESJAK2GCGR | |
| SCHEMBL3790890 | 0.79 | PTGES (0.53) | PTGESJAK2GCGR | |
| SCHEMBL3795105 | 0.79 | PTGES (0.52) | PTGESJAK2ORAI1GCGR | |
| SCHEMBL3797910 | 0.77 | PTGES (0.50) | PTGESJAK2ORAI1GCGRSCN2A | |
| SCHEMBL3796421 | 0.76 | PTGES (0.54) | PTGESJAK2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |