Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790890 | 0.91 | PTGES (0.53) | PTGESSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL3795105 | 0.90 | PTGES (0.52) | PTGESSMN1; SMN2LMNATP53MAPT | |
| SCHEMBL3800707 | 0.89 | PTGES (0.60) | PTGESALDH1A1JAK2GCGR | |
| SCHEMBL3796557 | 0.86 | PTGES (0.53) | PTGESSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL3799678 | 0.86 | PTGES (0.54) | PTGESSMN1; SMN2HTTGCGR | |
| SCHEMBL13075531 | 0.85 | LMNA (0.50) | PTGESSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3802423 | 0.83 | PTGES (0.57) | PTGESSMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL3792008 | 0.82 | PTGES (0.62) | PTGESSCN2AJAK2GCGR | |
| SCHEMBL3797105 | 0.77 | PTGES (0.55) | PTGESSCN2AJAK2GCGRORAI1 | |
| SCHEMBL3796421 | 0.77 | PTGES (0.54) | PTGESSMN1; SMN2JAK2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |