Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 19/20 | 0.46 |
| ▸ | OXTR | P30559 | 3/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794899 | 0.92 | AVPR1B (0.43) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL3803451 | 0.92 | KDM4E (0.42) | AVPR1BOXTRAVPR1A | |
| SCHEMBL1591735 | 0.91 | AVPR1B (0.54) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL3797266 | 0.91 | AVPR1B (0.46) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL6526334 | 0.91 | AVPR1B (0.51) | AVPR1BOXTRAVPR1ACHRM2CHRM4 | |
| SCHEMBL1795556 | 0.90 | AVPR1B (0.43) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL27800666 | 0.89 | KDM4E (0.41) | AVPR1BOXTRAVPR1A | |
| SCHEMBL15279969 | 0.88 | ALDH1A1 (0.37) | AVPR1BOXTRAVPR1AAVPR2CHRM2 | |
| SCHEMBL15279958 | 0.88 | ALDH1A1 (0.37) | AVPR1BOXTRAVPR1AAVPR2CHRM2 | |
| SCHEMBL6521609 | 0.88 | AVPR1B (0.51) | AVPR1BOXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231645-A2 | 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSINE-DEPENDENT DISEASES | Abbott GmbH & Co. KG (DE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009071689-A2 | 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSINE-DEPENDENT DISEASES | ABBOTT GMBH & CO. KG (DE) | 2009-06-11 | — | — | WO | disclosed |