Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 2/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790221 | 0.87 | CDC25B (0.44) | POLBCDC25BCDC25ACDC25CKDM4E | |
| SCHEMBL1310922 | 0.78 | PTPN2 (0.53) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28420937 | 0.76 | POLB (0.49) | POLBCDC25BCDC25ACDC25CKDM4E | |
| SCHEMBL3790215 | 0.75 | PIM1 (0.50) | POLBCDC25BCDC25ACDC25CKDM4E | |
| SCHEMBL3587879 | 0.70 | GUCY1A1 (0.52) | POLBKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3789561 | 0.69 | CSNK2B (0.45) | KDM4EMAPTTP53KMT2AMEN1 | |
| SCHEMBL16516735 | 0.68 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3794469 | 0.68 | KDM4E (0.46) | POLBCDC25BCDC25ACDC25CKDM4E | |
| SCHEMBL3784901 | 0.68 | SMN1; SMN2 (0.45) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2825604 | 0.67 | SMN1; SMN2 (0.47) | POLBCDC25BCDC25ACDC25CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135571-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |