Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861949 | 0.92 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL856735 | 0.92 | PIK3CD (0.40) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL861306 | 0.91 | PIK3CD (0.35) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL855650 | 0.91 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL3810593 | 0.91 | PIK3CD (0.35) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL3806861 | 0.91 | LMNA (0.39) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL861903 | 0.91 | PIK3CD (0.35) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL856695 | 0.90 | PIK3CD (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL861780 | 0.90 | PIK3CD (0.49) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL855905 | 0.90 | GPR142 (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |