Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.62 |
| ▸ | GSK3B | P49841 | 8/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.62 |
| ▸ | PIM1 | P11309 | 6/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.62 |
| ▸ | CLK2 | P49760 | 4/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.62 |
| ▸ | CDK2 | P24941 | 4/20 | 0.62 |
| ▸ | GSK3A | P49840 | 4/20 | 0.62 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.62 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637752 | 0.77 | ROCK2 (1.00) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL24137790 | 0.75 | CCNC (0.63) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL2455100 | 0.73 | GSK3B (1.00) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL17856787 | 0.72 | ABL1 (0.57) | CLK4ATRMAPK1CDC7AURKA | |
| SCHEMBL3671375 | 0.70 | ROCK2 (1.00) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL30805622 | 0.70 | GSK3B (0.63) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL17860575 | 0.70 | MAPT (0.55) | CLK4KDRCLK1MAPK1JAK2 | |
| SCHEMBL3670035 | 0.69 | ROCK2 (0.66) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL2457760 | 0.69 | GSK3B (0.66) | ROCK2GSK3BAURKBPIM1DYRK1A | |
| SCHEMBL2145233 | 0.68 | JAK2 (0.49) | ROCK2GSK3BAURKBPIM1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |