Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 1.00 |
| ▸ | CLK1 | P49759 | 2/20 | 1.00 |
| ▸ | CLK2 | P49760 | 2/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 2/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 2/20 | 1.00 |
| ▸ | DYRK3 | O43781 | 1/20 | 1.00 |
| ▸ | CLK3 | P49761 | 1/20 | 1.00 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 1.00 |
| ▸ | DYRK2 | Q92630 | 1/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.73 |
| ▸ | TRPA1 | O75762 | 9/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.60 |
| ▸ | PIM1 | P11309 | 4/20 | 0.60 |
| ▸ | CDC7 | O00311 | 4/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28247510 | 0.87 | GSK3B (0.76) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL2460902 | 0.85 | FGFR1 (1.00) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL4791316 | 0.83 | CLK1 (1.00) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL16573980 | 0.83 | GSK3B (0.71) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL16740690 | 0.83 | NOS1 (0.72) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL27663173 | 0.83 | FGFR1 (0.74) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL27074803 | 0.82 | GSK3B (0.70) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL758312 | 0.82 | FGFR1 (0.77) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL29354575 | 0.82 | FGFR1 (0.77) | GSK3BCLK4CLK1CLK2CDK5 | |
| SCHEMBL13680578 | 0.82 | GSK3B (0.70) | GSK3BCLK4CLK1CLK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230052747-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF TUMORS | TES PHARMA S.R.L. (IT) | 2023-02-16 | — | — | US | disclosed |
| US-20200390774-A1 | TRPA1 ANTAGONISTS FOR USE IN THE TREATMENT OF ATOPIC DERMATITIS | GALDERMA RES & DEV (FR) | 2020-12-17 | — | — | US | disclosed |
| US-20190307758-A1 | TRPA1 ANTAGONISTS FOR USE IN THE TREATMENT OF ATOPIC DERMATITIS | NESTLÉ SKIN HEALTH SA (CH) | 2019-10-10 | — | — | US | disclosed |
| CN-104557942-B | A kind of synthetic method of nitrogenous fused ring compound | 温州大学 | 2016-08-24 | — | — | CN | disclosed |
| CN-103980280-B | A kind of method of synthetic quinazolinone indazole derivative under acid condition | WENZHOU UNIVERSITY (CN) | 2016-05-04 | — | — | CN | disclosed |
| CN-103992325-B | A kind of synthetic method of N-phenyl indazole [3,2-b] quinazoline-7 (5H)-one derivative | WENZHOU UNIVERSITY (CN) | 2015-12-09 | — | — | CN | disclosed |
| CN-105121418-A | Benzothiazol- 6 -yl acetic acid derivatives and their use for treating an hiv infection | GILEAD SCIENCES INC | 2015-12-02 | — | — | CN | disclosed |
| CN-103664963-B | Method for synthesizing quinazolino indazole derivatives | UNIV WENZHOU | 2015-07-01 | — | — | CN | disclosed |
| CN-104557942-A | Synthetic method of nitrogen-containing fused ring compound | UNIV WENZHOU | 2015-04-29 | — | — | CN | disclosed |
| CN-103992325-A | Method for synthesizing N-phenyl indazole [3,2-b] quinazoline-7(5H)-ketone derivatives | UNIV WENZHOU | 2014-08-20 | — | — | CN | disclosed |
| CN-103980280-A | Method for synthesizing quinazolino indazole derivatives under acidic condition | UNIV WENZHOU | 2014-08-13 | — | — | CN | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
| WO-2010068287-A2 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190307758-A1 | TRPA1 ANTAGONISTS FOR USE IN THE TREATMENT OF ATOPIC DERMATITIS | TRPA1, TRPV1, TRPV2 | GSK3B 3348/4885CLK4 3725/4885CLK1 3349/4885 |
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | GSK3B 817/4885CLK4 4394/4885CLK1 3871/4885 |
| US-20230052747-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF TUMORS | RAD51, BRCA1, FANCI | GSK3B 970/4885CLK4 1779/4885CLK1 2750/4885 |
| US-20200390774-A1 | TRPA1 ANTAGONISTS FOR USE IN THE TREATMENT OF ATOPIC DERMATITIS | TRPA1, TRPV1, TRPV2 | GSK3B 3348/4885CLK4 3725/4885CLK1 3349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.