Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MPC2 | O95563 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798422 | 1.00 | PPARG (0.58) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL13347280 | 1.00 | PPARG (0.58) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL3801927 | 0.84 | PPARG (0.68) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL3801924 | 0.84 | PPARG (0.68) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL3792635 | 0.83 | PPARG (0.83) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL3792638 | 0.83 | PPARG (0.83) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL3585248 | 0.77 | HRH3 (0.50) | PPARGALDH1A1NPSR1FFAR1HRH3 | |
| SCHEMBL3797572 | 0.76 | PPARG (0.64) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL3797571 | 0.76 | PPARG (0.64) | PPARGMAOACISD1ALDH1A1NPSR1 | |
| SCHEMBL13347268 | 0.76 | PPARG (0.64) | PPARGMAOACISD1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2006-10-19 | — | — | US | claimed |
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | SEED, BRIAN | 2003-09-25 | — | — | US | claimed |
| US-7718682-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080293949-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-7407978-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1549625-A1 | NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS | Theracos, Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033438-A1 | NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS | THERACOS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | SEED, BRIAN | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885MAOA 3551/4885CISD1 1151/4885 |
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885MAOA 3551/4885CISD1 1151/4885 |
| US-20080293949-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885MAOA 3551/4885CISD1 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.