Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.33 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687324 | 0.78 | HCRTR1 (0.55) | HCRTR1HCRTR2NOTUMEGLN2 | |
| SCHEMBL18039131 | 0.72 | HCRTR1 (0.44) | HCRTR1HCRTR2NOTUMMAPK9MAPK10 | |
| SCHEMBL15006470 | 0.69 | DPP4 (0.39) | SYK | |
| SCHEMBL4561902 | 0.69 | NOTUM (0.37) | HCRTR1HCRTR2NOTUMMAPK9MAPK10 | |
| SCHEMBL16039381 | 0.68 | HCRTR2 (0.43) | HCRTR1HCRTR2NOTUMEGLN2 | |
| SCHEMBL3802779 | 0.67 | — | — | |
| SCHEMBL302595 | 0.67 | NOTUM (0.46) | HCRTR1HCRTR2NOTUMEGLN2MAPK9 | |
| SCHEMBL17910087 | 0.67 | HCRTR1 (0.43) | HCRTR1HCRTR2NOTUMMAPK9MAPK10 | |
| SCHEMBL979253 | 0.66 | MAPK9 (0.38) | NOTUMMAPK9MAPK10 | |
| SCHEMBL7848026 | 0.66 | HCRTR1 (0.48) | HCRTR1HCRTR2NOTUMMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |