Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18039131 | 0.72 | HCRTR1 (0.44) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL3687324 | 0.70 | HCRTR1 (0.55) | NOTUMHCRTR1HCRTR2CYP1A2CYP2C9 | |
| SCHEMBL3798467 | 0.69 | HCRTR1 (0.36) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL302446 | 0.68 | HCRTR1 (0.46) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL3348565 | 0.66 | — | — | |
| SCHEMBL979253 | 0.66 | MAPK9 (0.38) | NOTUMMAPK9MAPK10 | |
| SCHEMBL7848026 | 0.66 | HCRTR1 (0.48) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL29415179 | 0.66 | DHODH (0.42) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL29415057 | 0.66 | NOTUM (0.38) | NOTUMMAPK9MAPK10CYP1A2CYP2C9 | |
| SCHEMBL18939334 | 0.65 | ACHE (0.39) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054790-A1 | AMIDE LINKED HETEROAROMATIC DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | claimed |