Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.71 |
| ▸ | GSK3B | P49841 | 7/20 | 0.71 |
| ▸ | GSK3A | P49840 | 6/20 | 0.71 |
| ▸ | KDR | P35968 | 4/20 | 0.71 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.71 |
| ▸ | CLK2 | P49760 | 4/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.71 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.71 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.71 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.71 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.71 |
| ▸ | CDK2 | P24941 | 2/20 | 0.71 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.71 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.71 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.71 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.71 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.71 |
| ▸ | PLK4 | O00444 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802860 | 0.83 | CLK4 (1.00) | CLK4GSK3BGSK3AKDRSTK17A | |
| SCHEMBL3802284 | 0.81 | PLK4 (0.68) | CLK4GSK3BGSK3AKDRSTK17A | |
| SCHEMBL3795773 | 0.80 | CLK4 (0.74) | CLK4GSK3BGSK3AKDRSTK17A | |
| SCHEMBL9191959 | 0.78 | KMT2A (0.71) | KDREPHX2TRPV1MEN1MAPT | |
| SCHEMBL30772272 | 0.78 | EPHX2 (0.87) | KDRFGFR1EPHX2TRPV1MEN1 | |
| SCHEMBL27299059 | 0.77 | CLK4 (0.63) | CLK4GSK3BGSK3AKDRSTK17A | |
| SCHEMBL10008456 | 0.77 | CLK4 (1.00) | CLK4GSK3BGSK3AKDRSTK17A | |
| SCHEMBL9192658 | 0.76 | AHR (0.67) | KDREPHX2MEN1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL9390453 | 0.75 | L3MBTL1 (0.64) | CLK4GSK3BGSK3AKDRSTK17A | |
| SCHEMBL31060264 | 0.74 | CLK4 (1.00) | CLK4GSK3BGSK3AKDRSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856234-B2 | Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2018-01-02 | — | — | US | disclosed |
| US-20140148458-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-05-29 | — | — | US | disclosed |
| US-8642598-B2 | Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors | ABBVIE INC. (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2091943-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBVIE DEUTSCHLAND (DE) | 2013-11-20 | — | — | EP | disclosed |
| EP-2535336-A1 | Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors | Abbott GmbH & Co. KG (DE) | 2012-12-19 | — | — | EP | disclosed |
| US-20100324042-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG. (DE) | 2010-12-23 | — | — | US | disclosed |
| CN-101573352-A | Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO KG (DE) | 2009-11-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148458-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | GSK3B, GSK3A, GYS2 | CLK4 644/4885GSK3B 1/4885GSK3A 2/4885 |
| US-20100324042-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | GSK3B, GSK3A, GYS2 | CLK4 644/4885GSK3B 1/4885GSK3A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.