Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 12/20 | 0.61 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801487 | 0.92 | MAPKAPK5 (0.61) | MAPKAPK5 | |
| SCHEMBL3795246 | 0.91 | MAPKAPK5 (0.51) | MAPKAPK5ALKSYK | |
| SCHEMBL3805490 | 0.90 | MAPKAPK5 (0.53) | MAPKAPK5SYK | |
| SCHEMBL3802993 | 0.88 | MAPKAPK5 (0.48) | MAPKAPK5SYK | |
| SCHEMBL3801248 | 0.88 | MAPKAPK5 (0.47) | MAPKAPK5SYKMAP4K4 | |
| SCHEMBL1476556 | 0.87 | MAPKAPK5 (0.64) | MAPKAPK5KDM1AINSRALKSLC2A1 | |
| SCHEMBL3799041 | 0.86 | MAPKAPK5 (0.57) | MAPKAPK5KDM1AINSRALKSLC2A1 | |
| SCHEMBL3794624 | 0.83 | MAPKAPK5 (0.42) | MAPKAPK5 | |
| SCHEMBL3798405 | 0.83 | MAPKAPK5 (0.50) | MAPKAPK5MAP4K4 | |
| SCHEMBL3804104 | 0.82 | MAPKAPK5 (0.41) | MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |