Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 11/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796304 | 0.91 | MAPKAPK5 (0.38) | MAPKAPK5SYKJAK2JAK1 | |
| SCHEMBL3802993 | 0.89 | MAPKAPK5 (0.48) | MAPKAPK5SYKJAK2JAK1PTK2 | |
| SCHEMBL1476975 | 0.89 | MAPKAPK5 (0.58) | MAPKAPK5SYKTNIKSTAT6MAP4K4 | |
| SCHEMBL3798752 | 0.88 | MAPKAPK5 (0.61) | MAPKAPK5SYKMAP4K4 | |
| SCHEMBL3801487 | 0.88 | MAPKAPK5 (0.61) | MAPKAPK5 | |
| SCHEMBL3805490 | 0.86 | MAPKAPK5 (0.53) | MAPKAPK5SYKSTAT6PTK2 | |
| SCHEMBL3795246 | 0.85 | MAPKAPK5 (0.51) | MAPKAPK5SYK | |
| SCHEMBL3803732 | 0.80 | MAPKAPK5 (0.38) | MAPKAPK5SYKJAK2JAK1 | |
| SCHEMBL1476985 | 0.80 | MAPKAPK5 (0.48) | MAPKAPK5SYKJAK2JAK1 | |
| SCHEMBL2217998 | 0.79 | MAPKAPK5 (0.74) | MAPKAPK5TNIKMAP4K4WEE1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |