Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1476412 | 0.88 | MAPKAPK5 (0.49) | MAPKAPK5LCKJAK3BTKEGFR | |
| SCHEMBL3795246 | 0.88 | MAPKAPK5 (0.51) | MAPKAPK5JAK3SYKTGFBR1ACVR1 | |
| SCHEMBL3804104 | 0.85 | MAPKAPK5 (0.41) | MAPKAPK5 | |
| SCHEMBL3798752 | 0.80 | MAPKAPK5 (0.61) | MAPKAPK5LCKSYK | |
| SCHEMBL3801487 | 0.80 | MAPKAPK5 (0.61) | MAPKAPK5BTK | |
| SCHEMBL1475927 | 0.79 | MAPKAPK5 (0.61) | MAPKAPK5LCKJAK3BTKEGFR | |
| SCHEMBL3805490 | 0.79 | MAPKAPK5 (0.53) | MAPKAPK5PTK2SYK | |
| SCHEMBL3802993 | 0.79 | MAPKAPK5 (0.48) | MAPKAPK5BTKJAK2PTK2SYK | |
| SCHEMBL3794624 | 0.77 | MAPKAPK5 (0.42) | MAPKAPK5TTK | |
| SCHEMBL3798405 | 0.77 | MAPKAPK5 (0.50) | MAPKAPK5BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |