Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380013 | 0.86 | MAPK13 (0.46) | MAPK14MAPK1MAPK13RAF1 | |
| SCHEMBL379978 | 0.84 | MAPK13 (0.51) | MAPK14MAPK1MAPK13MAP3K5RAF1 | |
| SCHEMBL380269 | 0.82 | MAPK14 (0.48) | MAPK14MAPK1MAPK13MAP3K5 | |
| SCHEMBL380899 | 0.81 | MAPK14 (0.56) | MAPK14MAPK13RAF1RIPK2 | |
| SCHEMBL379934 | 0.74 | MAPK14 (0.49) | MAPK14MAPK1MAPK13RAF1 | |
| SCHEMBL379772 | 0.74 | MAPK14 (0.56) | MAPK14MAPK1MAPK13RAF1 | |
| SCHEMBL380017 | 0.73 | MAPK13 (0.53) | MAPK14MAPK1MAPK13RAF1 | |
| SCHEMBL379705 | 0.71 | MAPK14 (0.55) | MAPK14MAPK1MAPK13RAF1 | |
| SCHEMBL379509 | 0.71 | MAPK13 (0.51) | MAPK14MAPK13RAF1BRAF | |
| SCHEMBL437849 | 0.70 | MAPK13 (0.53) | MAPK14MAPK1MAPK13RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |