Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380269 | 0.90 | MAPK14 (0.48) | MAPK13MAPK14MAPK1MAP3K5LMNA | |
| SCHEMBL379819 | 0.86 | MAPK13 (0.67) | MAPK13MAPK14MAPK1RAF1 | |
| SCHEMBL379915 | 0.84 | MAPK14 (0.39) | MAPK13MAPK14MAPK1RIPK2MAP3K5 | |
| SCHEMBL379964 | 0.81 | MAPK13 (0.73) | MAPK13MAPK14RIPK2RAF1 | |
| SCHEMBL379772 | 0.81 | MAPK14 (0.56) | MAPK13MAPK14MAPK1RAF1 | |
| SCHEMBL380017 | 0.80 | MAPK13 (0.53) | MAPK13MAPK14MAPK1RAF1 | |
| SCHEMBL379705 | 0.80 | MAPK14 (0.55) | MAPK13MAPK14MAPK1RAF1 | |
| SCHEMBL379894 | 0.79 | MAPK13 (0.53) | MAPK13MAPK14MAPK1RAF1 | |
| SCHEMBL437849 | 0.79 | MAPK13 (0.53) | MAPK13MAPK14MAPK1RAF1 | |
| SCHEMBL380069 | 0.76 | MAPK13 (0.56) | MAPK13MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |